Antimicrobial susceptibilities and distribution of sequence types of Neisseria gonorrhoeae isolates in Canada: 2010
The monitoring of antimicrobial susceptibilities in Neisseria gonorrhoeae isolates and characterization of N.
gonorrhoeae multiantigen sequence types (NG-MAST, ST) provide important surveillance data as resistance rates continue to rise. A total of 2970 N.
gonorrhoeae isolates were collected by Canadian provincial public health laboratories in 2010, and 1233 were submitted to the National Microbiology Laboratory for testing. The NG-MAST and minimum inhibitory concentration (MIC) by agar dilution were determined for each isolate. Of the
2970 isolates, 25.1% were resistant to penicillin, 34.6% resistant to tetracycline, 31.5% resistant to erythromycin, 35.9% resistant to ciprofloxacin, and 1.2% resistant to azithromycin. Decreased susceptibility to cefixime (MIC ≥ 0.25 mg/L) and ceftriaxone (MIC ≥ 0.125 mg/L) was identified
in 3.2% and 7.3% of the isolates, respectively. The most common STs found in Canada were ST1407 (13.3%), ST3150 (11.3%), and ST3158 (9.0%), with 249 different STs identified among the isolates. Within the ST1407 group, 19.5% and 43.3% isolates have decreased susceptibility to cefixime and
ceftriaxone, respectively. ST1407, the most prevalent NG-MAST in Canada in 2010, has been associated with high-level ceftriaxone MICs and with cefixime treatment failure cases worldwide. Identification and monitoring of STs and corresponding antimicrobial resistance profiles may be useful
in surveillance programs and be used to inform public health actions.
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types de séquences
Document Type: Research Article
Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, MB R3E 3R2, Canada.
Public Health Ontario Laboratories, Toronto, Ont., Canada.
Laboratoire de santé publique du Québec, Ste-Anne-de-Bellevue, Que., Canada.
British Columbia Centre for Disease Control Public Health Microbiology & Reference Laboratory, Vancouver, B.C., Canada.
Provincial Laboratory for Public Health, Edmonton, Alta., Canada.
Queen Elizabeth II Health Sciences Centre, Halifax, N.S., Canada.
Cadham Provincial Laboratory, Winnipeg, Man., Canada.
Saskatchewan Disease Control Laboratory, Regina, Sask., Canada.
Hôpital Dr G.L. Dumont, Moncton, N.B., Canada.
Newfoundland Provincial Laboratory, St. John’s, N.L., Canada.
Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, Ont., Canada.
January 1, 2013
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