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New ways to skin a kap: mechanisms for controlling nuclear transport

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Transport between the nucleus and the cytoplasm occurs through large macromolecular assemblies called nuclear pore complexes (NPCs). The NPC is traditionally viewed as a passive structure whose primary role is to provide an interface for the soluble transport machinery, the karyopherins and their cargos, to move molecules between these compartments. Recent work has challenged this view of the NPC and provides support for a dynamic structure that can modify its architecture to actively regulate nuclear transport.Key words: nuclear transport, nuclear pore complex, karyopherin, nucleoporin.

Le transport entre le noyau et le cytoplasme se déroule à travers de gros assemblages macromoléculaires appelés : « complexes des pores nucléaires » (CPN). Le CPN est traditionnellement considéré comme étant une structure passive dont le premier rôle est de fournir une interface pour la machinerie soluble de transport, les karyophérines et leurs cargos, qui assurent le mouvement des molécules entre ces compartiments. Des travaux récents ont mis en doute ce point de vue sur les CPN et supportent l'idée d'une structure dynamique qui peut modifier son architecture afin de réguler activement le transport nucléaire.Mots clés : transport nucléaire, complexe des pores nucléaires, karyophérines, nucléoporines.[Traduit par la Rédaction]
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Document Type: Research Article

Publication date: December 1, 2004

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