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Nutritional recovery from a low-protein diet during pregnancy does not restore the kinetics of insulin secretion and Ca2+ or alterations in the cAMP/PKA and PLC/PKC pathways in islets from adult rats

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We investigated the insulin release induced by glucose, the Ca2+ oscillatory pattern, and the cyclic AMP (cAMP)/protein kinase A (PKA) and phospholipase C (PLC)/protein kinase C (PKC) pathways in islets from adult rats that were reared under diets with 17% protein (C) or 6% protein (LP) during gestation, suckling, and after weaning and in rats receiving diets with 6% protein during gestation and 17% protein after birth (R). First-phase glucose-induced insulin secretion was reduced in LP and R islets, and the second phase was partially restored in the R group. Glucose stimulation did not modify intracellular Ca2+ concentration, but it reduced the Ca2+ oscillatory frequency in the R group compared with the C group. Intracellular cAMP concentration was higher and PKA-Cα expression was lower in the R and LP groups compared with the C group. The PKCα content in islets from R rats was lower than that in C and LP rats. Thus, nutritional recovery from a low-protein diet during fetal life did not repair the kinetics of insulin release, impaired Ca2+ handling, and altered the cAMP/PKA and PLC/PKC pathways.
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Keywords: Ca2+ oscillation; insulin secretion; nutritional recovery; oscillation du Ca2+; protein kinase A; protein kinase C; protéine kinase A; protéine kinase C; récupération nutritionnelle; sécrétion d’insuline

Document Type: Research Article

Affiliations: 1: Faculdade de Nutrição, Universidade Federal de Mato Grosso, Cuiabá-MT, 78060-900, Brazil. 2: Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Limeira-SP, 13484-350, Brazil. 3: Universidade Federal de São Paulo, Campus Baixada Santista, Santos-SP, 11015-020, Brazil. 4: Universidade Federal do Rio de Janeiro, Núcleo em Ecologia e desenvolvimento socioambiental, Rio de Janeiro-RJ, 21941-901, Brazil. 5: Departamento de Fisiologia e Farmacologia da Universidade Federal de Pernambuco, Recife-PE, 50670-901, Brazil.

Publication date: January 1, 2018

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