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Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle

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Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼–25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.
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Keywords: PGC-1α; energetic stress; exercice par intervalle d’intensité élevée; high-intensity interval exercise; stress énergétique

Document Type: Research Article

Publication date: January 1, 2015

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