No study has shown the effects of acute resistance exercise on vasodilatory capacity of patients with peripheral artery disease. The aim of this study was to analyse the effects of a single session of resistance exercise on blood flow, reactive hyperemia, plasma nitrite, and plasma
malondialdehyde in patients with peripheral artery disease. Fourteen peripheral artery disease patients underwent, in a random order, 2 experimental sessions: control (rest for 30 min) and resistance exercise (8 exercises, 2 sets of 10 repetitions at an intensity of 5–7 in the OMNI Resistance
Exercise Scale). Blood flow, reactive hyperemia, plasma nitrite, and malondialdehyde were measured before and 40 min after the interventions in both sessions. Data were compared between sessions by analysis of covariance, using pre-intervention values as covariates. The increases in blood
flow, reactive hyperemia, and log plasma nitrite were greater (p ≤ 0.05) after resistance exercise than the control session (3.2 ± 0.1 vs. 2.7 ± 0.1 mL·100 mL−1 tissue·min−1, 8.0 ± 0.1 vs. 5.7 ± 0.1 AU, and
1.36 ± 0.01 vs. 1.26 ± 0.01 μmolL−1, respectively). On the other hand, malondialdehyde was similar between sessions (p > 0.05). In peripheral arterial disease patients, a single session of resistance exercise increases blood flow and reactive hyperemia,
which seems to be mediated, in part, by increases in nitric oxide release.
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exercice de force;
maladie artérielle périphérique;
peripheral artery disease;
Document Type: Research Article
School of Physical Education, University of Pernambuco, Rua Arnóbio Marques, 310, Recife, Pernambuco 50.100-130, Brazil.
Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Department of Physical Education, University Federal of Paraíba, Paraíba, Brazil.
Procape University Hospital, University of Pernambuco, Pernambuco, Brazil.
January 1, 2015
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