Acute hyperinsulinemia reduces total and high molecular weight (HMW) adiponectin levels in humans. Whether an increase in insulin sensitivity (IS) is accompanied by a greater suppressive effect of hyperinsulinemia on adiponectin levels is unknown, however. To clarify the inhibitory
role of insulin on adiponectin, total and HMW adiponectin levels were measured during acute hyperinsulinemia before and after an improvement in insulin sensitivity in response to weight loss. Forty-six overweight and obese postmenopausal women were randomized to either 6-month caloric restriction
(CR) alone (n = 22), or CR with resistance training (CR+RT, n = 24). IS (hyperinsulinemic–euglycemic clamp) was assessed before and after weight loss. Total and HMW adiponectin levels were measured by ELISA at baseline, 90, 160, and 180 min of each clamp. Relative
mean body weight loss was –8.0% ± 4.4% for both groups (CR: –7.7% ± 3.8%; CR+RT: –8.2% ± 5.0%). IS increased significantly, by 18.4% ± 25.3% (CR: 19.3% ± 29.7%; CR+RT: 17.7% ± 21.0%). Before
each intervention, total and HMW adiponectin levels in both groups significantly decreased in response to hyperinsulinemia (total: –8.4% ± 19.4%; HMW: –3.2% ± 13.2%). Despite the improvement in IS seen after each intervention, a similar pattern
of reduction to that before weight loss was observed in total and HMW adiponectin levels during hyperinsulinemia. These results establish that total and HMW adiponectin levels decline during a hyperinsulinemic–euglycemic clamp. Also, the insulin-sensitizing effect of weight loss via
caloric restriction alone or with resistance training does not amplify the reduction in adiponectin levels observed during hyperinsulinemia in healthy postmenopausal women.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
entraînement en résistance;
Document Type: Research Article
Behavioral and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Institut de Recherche Clinique de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.
Faculty of Physical Education and Sports, University of Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
April 13, 2011
More about this publication?