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Peripheral expression of inflammatory markers in overweight female adolescents and eutrophic female adolescents with a high percentage of body fat

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The objective of this study was to evaluate the peripheral expression of inflammatory markers in adolescents with different nutritional status and its correlation with parameters of the metabolic syndrome. Seventy-two female postpubescent adolescents were divided into 3 groups: eutrophic (Co), eutrophic with a high body fat percentage (HBF), and overweight (OW). Data related to the parameters of the metabolic syndrome and the peripheral expression of tumour necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10 were evaluated. Higher values of glycemia and insulin resistance were found in the HBF group than in the Co group. No differences related to the peripheral expression of the cytokines were found among the groups. In the HBF group, a positive correlation was observed between TNF-α and IL-6, IL-10 and the proinflammatory cytokines, and IL-6 and glycemia. In the OW group, a positive correlation was found between IL-6 and triglycerides. Adolescents with normal weight but body fat excess present a metabolic profile and body composition similar to those of overweight adolescents. This suggests that these adolescents have a risk of developing cardiovascular diseases similar to that of overweight adolescents. The positive correlation between IL-10 and TNF-α and IL-6 suggests an attempt to inhibit the production of these cytokines by IL-10.

Cette étude se propose d’évaluer l’expression périphérique des marqueurs de l’inflammation chez des adolescents de statut nutritionnel différent et sa corrélation avec le syndrome métabolique. On répartit 72 adolescentes postpubertaires dans trois groupes : eutrophique (Co), eutrophique avec un fort pourcentage de gras (HBF) et en surpoids (OW). On évalue les variables en lien avec le syndrome métabolique et l’expression périphérique de TNF-α, IL-6 et IL-10. Comparativement au groupe Co, le groupe HBF présente des valeurs de glycémie et d’insulinorésistance supérieures. On n’observe aucune différence entre les groupes en qui concerne l’expression périphérique des cytokines. Chez le groupe HBF, on observe des corrélations positives entre TNF-α et IL-6, entre IL-10 et les cytokines pro-inflammatoires et entre IL-6 et la glycémie. Chez le groupe OW, on observe une corrélation positive entre IL-6 et les triglycérides. Les adolescentes de poids normal avec un surplus de gras corporel et les adolescentes en surpoids présentent un profil métabolique et une composition corporelle similaires. D’après ces observations, ces deux groupes d’adolescentes risquent de développer les mêmes maladies cardiovasculaires. La corrélation positive observée entre IL-10 et TNF-α et IL-6 suggère que les IL-10 tentent d’inhiber la production des cytokines.
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Document Type: Research Article

Publication date: August 1, 2010

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