To evaluate the effects of epsilon aminocaproic acid (EACA) on the prevalence of postoperative bleeding in retired racing Greyhounds (RRG), and to
assess its effects on selected thrombelastography (TEG) and fibrinolysis variables. Study Design
Double‐blinded, prospective, randomized study.
100 RRG had elective ovariohysterectomy or orchiectomy and were administered EACA or placebo for 3 days after surgery. TEG variables were analyzed preoperatively
and 24, 48, and 72 hours after surgery. Results
Thirty percent (15/50) of RRG in the placebo group had delayed postoperative bleeding starting 36–48 hours after
surgery compared with 10% (5/50) in the EACA group (P = .012). On the TEG variables, the slopes for R and K time were significantly different between treatment groups (P
<.05); the R and K time decreased over time in the EACA group after surgery whereas they increased in the placebo group. The angle, maximal amplitude (MA), and G slopes were also significantly different
between treatment groups (P = .001, .001, and .006, respectively). The angle, MA, and G increased postoperatively over time in the EACA group and decreased in the placebo group. All these changes are
supportive of hypercoagulability associated with EACA administration. Conclusion
Postoperative administration of EACA significantly decreased the
prevalence of postoperative bleeding in RRG undergoing surgery by increasing the clot strength.
No Supplementary Data
No Article Media
Document Type: Research Article
Publication date: July 1, 2012