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Evaluation of a Percutaneously Controlled Hydraulic Occluder in a Rat Model of Gradual Venous Occlusion

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Objective

To evaluate the efficacy of a percutaneously controlled hydraulic occluder (HO) in a rat model of gradual venous occlusion. Study Design

Experimental study. Animals

Ten male Sprague–Dawley rats. Methods

HOs and perivascular transit time ultrasound flow probes were applied to the caudal vena cava (CVC). Occluders in group I rats (n=6) were gradually attenuated over 8 weeks, whereas occluders in group II rats (n=4) were not attenuated. Vena caval blood flow measurements were performed weekly in all rats for 8 weeks. After euthanasia, the CVC was evaluated grossly and by histopathology. Results

Premature occlusion of the vena cava occurred during the 1st week in 3 rats (1 in group I, 2 in group II) because of kinking of the vena cava between the HO and the flow probe. For the remaining rats, mean blood flow in group I decreased significantly from 40.71 mL/min/kg at baseline to 4.68 mL/min/kg at 8 weeks (P=.0094, power=0.91). Group II rats maintained vena caval blood flow at all times during the study. Complete occlusion of the vena cava was confirmed at necropsy in all group I rats. Conclusions

Gradual occlusion of the CVC of rats was achieved with HOs over 8 weeks. This model is limited by the size of the experimental animals and comparatively large implants. Clinical Relevance

HOs may provide a method for gradual occlusion of congenital portosystemic shunts.
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Keywords: hyaluronate; hydraulic occluder; portosystemic shunt; rat; vascular occlusion; vena cava

Document Type: Research Article

Affiliations: From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL

Publication date: January 1, 2005

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