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Evaluation of Samarium-153 for Synovectomy in an Osteochondral Fragment-Induced Model of Synovitis in Horses

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To determine the effects of intraarticular administration of Samarium-153 (153Sm) bound to hydroxyapatite microspheres (153SmM) on an osteochondral chip–Ninduced synovitis. Study Design

Sixty days after implantation of autogenous osteochondral fragments in the middle carpal and metacarpophalangeal joints, 153SmM was administered into 1 joint of each type. The contralateral joints were used as untreated controls. Animals or Sample Population

Fifteen horses without preexisting joint disease were randomly divided into 2 groups (7 in the carpal group, 8 in the metacarpophalangeal group). Methods

Horses had osteochondral fragments that were harvested from the lateral ridge of the trochlea of the talus and implanted bilaterally into a middle carpal joint and a metacarpophalangeal joint; the opposite joint type served as a control. Sixty days later, 10 to 15 mCi of 153SmM (20 to 50 m diam) was injected into the fragment-implanted joints. Three horses were treated with nonradioactive hydroxyapatite fragments. Horses were examined clinically until they were killed 14 or 30 days later. Control and treated joints were examined grossly and microscopically to determine the effects of 153SmM on synovial membrane and cartilage. Results

Intraarticular 153SmM caused a transient flare with lameness, effusion, and edema for 48 to 72 hours. Implanted osteochondral chips induced a synovitis characterized by variable degrees of joint damage and synovial infiltrate. Use of 153SmM resulted in synovectomy of variable depth and extent. Conclusions

Intraarticular 153SmM may be a useful method for synovectomy of inflamed synovial membrane. Clinical Relevance

With further testing, radioactive pharmaceuticals might become useful clinical treatments for persistent synovitis not responsive to conventional techniques.

© Copyright 2000 by The American College of Veterinary Surgeons
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Document Type: Research Article

Affiliations: From the Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, and the Arthritis-Immunology Center, Veterans Administration Medical Center, Philadelphia, PA.

Publication date: May 1, 2000

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