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Effects of mydriatics on intraocular pressure and pupil size in the normal feline eye

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Abstract Objective 

To determine the effect of various mydriatics (1% atropine, 1% cyclopentolate, 0.5% tropicamide, 10% phenylephrine) on intraocular pressure (IOP) and pupil size (PS) in normal cats. Animals studied 

The mydriatics were tested in 10 adult ophthalmoscopically normal European Domestic Short-haired cats. Procedure 

Single-dose drug studies were divided into placebo (vehicle of phenylephrine), 10% phenylephrine, 0.5% tropicamide, 1% cyclopentolate and 1% atropine. After measurement of IOP and pupil size (PS) at 8 a.m. on the first day, one drop of the tested drug was applied to one randomly selected eye. The IOP and PS were measured for a minimum of 36 h until the pupil returned to pretest size. Results 

Ten per cent phenylephrine had no significant effect on IOP, and the effect on the pupil size was minimal (≤ 1 mm difference). One per cent atropine showed a maximal mean difference of 4.3 mmHg ± 4.1 mmHg in IOP compared to the untreated eye. These differences were statistically significant at 1, 3, 6, 12 and 16 h post-treatment. At 1, 1.5 and 2 h after unilateral application of 1% cyclopentolate, the IOP in the treated eye was significantly higher than the IOP in the untreated eye with a maximal mean difference of 4.1 mmHg ± 4.5 mmHg. With 0.5% tropicamide, IOP of the treated eye was significantly higher than IOP of the untreated eye at 1 and 1.5 h after treatment with a maximal mean difference of 3.5 mmHg ± 3.3 mmHg. One per cent atropine caused the greatest increase in IOP, followed by 1% cyclopentolate and 0.5% tropicamide. The dilating effect of atropine, cyclopentolate and tropicamide lasted longer than the effect on intraocular pressure. Conclusions 

The parasympatholytics 1% atropine, 1% cyclopentolate and 0.5% tropicamide caused a statistically significant elevation of IOP and produced mydriasis in the treated eye in normal cats, while the sympathomimetic 10% phenylephrine had no significant effect on IOP or pupil size.
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Keywords: cat; intraocular pressure; mydriatics; parasympatholytics; pupil; sympathomimetics

Document Type: Research Article

Affiliations: 1: Clinic for Surgery and Ophthalmology, Veterinärplatz 1, 1210 Vienna, Austria; 2: Department of Medical Statistics, Medical University Vienna, Spitalgasse 23, 1090 Vienna, Austria

Publication date: July 1, 2006

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