Low-dose recombinant canine interferon-γ for treatment of canine atopic dermatitis: An open randomized comparative trial of two doses
The purpose of this study was to investigate the minimum effective dose of recombinant canine interferon-γ (rCaIFN-γ) for the treatment of dogs with atopic dermatitis (AD). Thirty-four dogs with AD from 17 animal hospitals in Japan were administered half or one-fifth of the approved rCaIFN-γ dose of 10 000 units/kg, three times a week for 4 weeks, followed by once weekly for an additional 4 weeks. Pruritus, excoriation, erythema and alopecia were evaluated and scored by the investigators on weeks 2, 4, 6, 8 and 12. The efficacy rate (number of excellent cases + number of good cases/total number of cases) at week 8 in the 2000 units/kg group was 36.4% for pruritus, 36.4% for excoriation, 45.5% for erythema and 36.4% for alopecia. In contrast, in the 5000 units/kg group, the efficacy rate was 64.3% for pruritus, 57.1% for excoriation, 78.6% for erythema and 78.6% for alopecia. The efficacy rate of the 5000 units/kg group was high for all signs evaluated and comparable to that of the 10 000 units/kg group reported in a previous study. The results of this study showed that 2000 units/kg of rCaIFN-γ is less effective than 5000 units/kg to treat dogs with AD, and the efficacy of the 5000 units/kg dose is comparable to that of 10 000 units/kg at week 8.
Document Type: Research Article
Affiliations: 1: Sanyo Animal Medical Center, 357-1, Koumoto, Akaiwa, Okayama 709-0821, Japan 2: Hokuai Animal Hospital, 2-10, N12, E13, Higashi-ku, Sapporo Hokkaido 065-0012, Japan 3: Shibasaki Animal Hospital, 1-10-35, Ushidahon-cho, Higashi-ku, Hiroshima 732-0066, Japan 4: Amica Pet Clinic, 3-2-3, Onda-cho, Ube, Yamaguchi 755-0023, Japan 5: Maruyama Animal Hospital, 11-1-37, Miyanomori 1-jou, Chuo-ku, Sapporo, Hokkaido 064-0951, Japan 6: Pet Clinic Anihos, 1-14-11, Minamitokiwadai, Itabashi-ku, Tokyo 174-0072, Japan 7: Takenaka Animal Hospital, 3-10-3, Zao-cho, Fukuyama, Hiroshima 721-0971, Japan 8: Matsumura Animal Hospital, 2239-26, Kokubu-cho, Hamada, Shimane 697-0003, Japan 9: Uno Animal Hospital, 181-3, Yamadai, Kinsei-cho, Shikokuchuo, Ehime 799-0112, Japan 10: Veterinary ME Research Center Co. Ltd., 482-3, Ina, Akiruno, Tokyo 190-0142, Japan 11: Takehara Animal Hospital, 304-4, Asakawahigashi-jou, Nagano 381-0064, Japan 12: Medical Center Nishida Animal Hospital, 5-10-11, Ueda, Matsubara, Osaka 580-0016, Japan 13: Kadoya Animal Hospital, Fuchu 1-40-12, Fuchu, Tokyo 183-0055, Japan 14: Kariya Animal Hospital, 3-12-7, Kitasuna, Koto-ku, Tokyo 136-0073, Japan 15: Kato Animal Hospital, 2-286-12, Matsunami-cho, Tottori 680-0801, Japan 16: Yonago Animal Medical Center, 5-6-17, Yonehara, Yonago, Tottori 683-0804, Japan 17: Ishiyama-dori Animal Hospital, 1-25, S17, W10, Chuo-ku, Sapporo 064-0917, Japan
Publication date: February 1, 2010