@article {Chenge‐Espinosa:2018:0960-7412:828,
title = "Shedding light on the methylerythritol phosphate (MEP)pathway: long hypocotyl 5 (HY5)/phytochromeinteracting factors (PIFs) transcription factors modulating key limiting steps",
journal = "The Plant Journal",
parent_itemid = "infobike://bsc/tpj",
publishercode ="bp",
year = "2018",
volume = "96",
number = "4",
publication date ="2018-11-01T00:00:00",
pages = "828-841",
itemtype = "ARTICLE",
issn = "0960-7412",
eissn = "1365-313X",
url = "https://www.ingentaconnect.com/content/bsc/tpj/2018/00000096/00000004/art00011",
doi = "doi:10.1111/tpj.14071",
keyword = "long hypocotyl 5, Arabidopsis thaliana, DXR and HDR enzymes, light responses, isoprenoids, rate‐limiting enzymes, DXS1, phytochrome‐interacting factors, MEP pathway",
author = "ChengeEspinosa, Marel and Cordoba, Elizabeth and RomeroGuido, Cynthia and ToledoOrtiz, Gabriela and Le{\’o}n, Patricia",
abstract = "The plastidial methylerythritol phosphate (MEP) pathway is an essential route for plants as the source of precursors for all plastidial isoprenoids, many of which are of medical and biotechnological importance. The MEP pathway is highly sensitive to environmental cues as many of these
compounds are linked to photosynthesis and growth and light is one of the main regulatory factors. However, the mechanisms coordinating the MEP pathway with light cues are not fully understood. Here we demonstrate that by a differential direct transcriptional modulation, via the keymaster
integrators of light signal transduction HY5 and PIFs which target the genes that encode the ratecontrolling DXS1, DXR and HDR enzymes, light imposes a direct, rapid and potentially multifaceted response that leads to unique protein dynamics of this pathway,
resulting in a significant difference in the protein levels. For DXS1, PIF1/HY5 act as a direct activation/suppression module. In contrast, DXR accumulation in response to light results from HY5 induction with minor contribution of derepression by PIF1. Finally, HDR
transcription increases in the light exclusively by suppression of the PIFs repression. This is an example of how light signaling components can differentially multitarget the initial steps of a pathway whose products branch downstream to all chloroplastic isoprenoids. These findings
demonstrate the diversity and flexibility of light signaling components that optimize key biochemical pathways essential for plant growth.",
}