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Free Content DOMINO1, a member of a small plant-specific gene family, encodes a protein essential for nuclear and nucleolar functions

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Arabidopsis embryos carrying the domino1 mutation grow slowly in comparison with wild type embryos and as a consequence reach only the globular stage at desiccation. The primary defect of the mutation at the cellular level is the large size of the nucleolus that can be observed soon after fertilization in the nuclei of both the embryo and the endosperm. The ultrastructure of mutant nucleoli is drastically different from wild type and points to a fault in ribosome biogenesis. DOMINO1 encodes a protein, which belongs to a plant-specific gene family sharing a common motif of unknown function, present in the tomato DEFECTIVE CHLOROPLASTS AND LEAVES (LeDCL) protein. Using a GFP protein fusion, we show that DOMINO1 is targeted to the nucleus. We propose that inactivation of DOMINO1 has a negative effect on ribosome biogenesis and on the rate of cell division.
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Keywords: Arabidopsis; embryogenesis; mutant; nucleolus; nucleus; ribosomes

Document Type: Research Article

Affiliations: 1: Laboratoire Génome et Développement des Plantes, CNRS-UMR 5096, Université de Perpignan, 52 Avenue de Villeneuve, 66860 Perpignan-cedex, France 2: BMEC/ITRI, 321 Kuang Fu Road, 300 Hsinchu, Taiwan 3: Station de Génétique et Amélioration des Plantes, Route de Saint-Cyr, 78026 Versailles-cedex, France

Publication date: September 1, 2004

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