Skip to main content
padlock icon - secure page this page is secure

Free Content Inhibition of systemic onset of post-transcriptional gene silencing by non-toxic concentrations of cadmium

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library


Post-transcriptional gene silencing (PTGS) is an important mechanism for regulation of plant gene expression and virus–plant interactions. To better understand this process, the heavy metal cadmium was identified as a specific inhibitor in two different PTGS systems, constitutive and inducible. The pattern of cadmium-induced inhibition of PTGS allowed several insights into PTGS development. First, cadmium treatment prevented only systemic but not local onset of PTGS, uncoupling between these two modes of PTGS. Second, non-toxic, but not toxic, levels of cadmium inhibited PTGS, suggesting induction of a pathway that interferes with PTGS. Third, cadmium effects on PTGS closely paralleled those on the movement of tobamoviruses, suggesting that both processes may share common steps in their systemic transport pathways. Interestingly, these effects of cadmium do not represent a general property of toxic metal ions because two other such elements, that is zinc and aluminum, did not interfere with PTGS and viral systemic movement.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: cadmium; gene silencing; heavy metal ions; post-transcriptional gene silencing (PTGS); systemic spread; tobamoviruses

Document Type: Research Article

Affiliations: Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, NY 11794–5215, USA

Publication date: November 1, 2001

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more