Low MBL‐associated serine protease 2 (MASP‐2) levels correlate with urogenital schistosomiasis in Nigerian children
The human mannose‐binding lectin (MBL) and ficolins (FCN) are involved in pathogen recognition in the first line of defence. They support activation of the complement lectin cascade in the presence of MBL‐associated serine protease 2 (MASP‐2), a protein that cleaves the C4 and C2 complement components. Recent studies found that distinct MBL2 and FCN2 promoter variants and their corresponding serum levels are associated with relative protection from urogenital schistosomiasis.
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