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Free Content Epidemiological studies of the non‐specific effects of vaccines: II – methodological issues in the design and analysis of cohort studies

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We review sources of bias which can affect non‐randomized cohort studies of non‐specific effects of vaccines on child mortality. Using examples from the literature on non‐specific effects, we describe different sources of selection and information bias, and, where possible, outline analysis strategies to mitigate or eliminate such biases.
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Keywords: efectos no específicos; effets non spécifiques; methodology; metodología; mortalidad; mortality; mortalité; méthodologie; non‐specific effects; vaccines; vaccins; vacunas

Language: English

Document Type: Research Article

Affiliations: 1:  Department of Mathematics and Statistics, The Open University, Milton Keynes, UK 2:  Telethon Institute for Child Health Research and Centre for Child Health Research, The University of Western Australia, Australia 3:  Division of International Health, Johns Hopkins University, Baltimore, MD, USA 4:  Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark 5:  Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark 6:  London School of Hygiene & Tropical Medicine, London, UK

Publication date: September 1, 2009

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