Lymphocyte subset changes between 3 and 15 months of age in infants born to HIV‐seropositive women in South Africa
The CD4 and CD8 T‐lymphocyte subsets, expressed in absolute numbers, as percentages, percentiles or as ratios, were clear indicators of HIV infection at all ages between 3 and 15 months. The most marked changes were a decreased percentage of CD4 cells and an increase in percentage of CD8 cells in the infected group. In the 4 infected infants who died, CD8 count and CD4:CD8 ratio clearly predicted poor clinical outcome at 3 months. Taken together, both CD4:CD8 ratio and CD4 percentage are reliable markers of HIV infection in an African paediatric population; however, a raised CD8 lymphocyte count rather than a CD4 count is a more specific prognostic marker of disease progression in HIV infected children.
Document Type: Original Article
Affiliations: 1: Department of Paediatrics and Child Health, University of Natal, Durban, South Africa, 2: Department of Haematology, University of Natal, Durban, South Africa, 3: MRC Centre for Epidemiological Research, Medical Research Council, Durban, South Africa
Publication date: May 1, 1997