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Relation between schizophrenia and Alzheimer's disease: the reelin signaling pathway

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Reelin is an extracellular matrix protein that is related to neuronal migration at the embryonic stage. Recently, the relation between reelin and schizophrenia and Alzheimer's disease was established. The authors summarize these two disorders from the perspective of the reelin signaling pathway. Reelin and reelin mRNA are reduced in the schizophrenic brain and Cajal–Retzius cells, which secrete reelin, are reduced in the Alzheimer's brain. From the reelin signaling pathway, a reduction or deficit of reelin leads to the disturbance of neuronal migration and abnormal phosphorylation of tau protein, and may be a pathologic factor involved in the etiology of schizophrenia and Alzheimer's disease. Reelin may be the common feature of both schizophrenia and Alzheimer's disease.
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Keywords: Alzheimer's disease; Cajal–Retzius cells; corticogenesis; reelin; schizophrenia; signaling pathway

Document Type: Research Article

Affiliations: Division of Anatomy and Developmental Neurobiology, Department of Neuroscience, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan

Publication date: June 1, 2005

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