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Evaluation of a computerized test system to screen for mild cognitive impairment

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Abstract Background: 

Mild cognitive impairment (MCI) refers to the clinical condition between normal aging and Alzheimer's disease (AD) and has a high probability of developing into AD. Early detection of MCI is important because early detection and appropriate follow-up treatment can prevent the disease from progressing. Therefore, MCI is an important candidate for screening and possible intervention. Methods: 

We have developed a computerized screening test system to identify cognitive decline. This system consists of six tests (age and year-of-birth validity test, three-word memory test, time orientation test, first modified delayed-recall test, visual working memory test and second modified delayed-recall test). The scores obtained from three groups (MCI patients, AD patients and healthy control subjects) were analyzed to evaluate the sensitivity and specificity required for the screening of MCI. Results: 

The system was well accepted by the patients. All of the test procedures were completed within 5 min. Significant group differences in all test results were found. The system has sensitivity and specificity values of 82% and 87%, respectively, when used as a screen for MCI. Conclusion: 

The system is useful for the screening of cognitive disorders.
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Keywords: Alzheimer's disease; computer; dementia; mild cognitive impairment; screening

Document Type: Research Article

Affiliations: 1: Department of Biological Regulation, School of Health Science, Faculty of Medicine and 2: Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan

Publication date: June 1, 2005

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