Staphylococcal toxic shock syndrome in a child with interleukin‐17 inhibitor treatment for psoriasis
A 6‐year‐old girl presented with fever, skin rash, anuria, and conjunctivitis that rapidly progressed to toxic shock syndrome. Following hospital discharge, she developed a staphylococcal abscess on the lower extremity. She had recently received the first two doses of
the interleukin‐17 (IL‐17) inhibitor secukinumab for resistant plaque psoriasis. IL‐17 is known to be essential in host defense against Staphylococcus aureus. To our knowledge, this is the first reported case of staphylococcal toxic shock syndrome (STSS) associated
with an IL‐17 inhibitor.
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Keywords: infection‐bacterial; pediatric; psoriasis; therapy‐systemic; toxic shock syndrome
Document Type: Research Article
Publication date: September 1, 2020