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Use of topical rapamycin in acral pseudolymphomatous angiokeratoma of children (APACHE): A report of two cases and review of the literature

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Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare, benign disease characterized clinically by multiple, asymptomatic, erythematous papules in the acral regions. We report APACHE in a 12‐year‐old girl with erythematous‐violaceous papules on the lateral dorsum of her foot and toes, and a 3‐year‐old girl with erythematous papules on the plantar aspect of her foot. Topical rapamycin ointment improved the lesions and both patients tolerated the medication well. Topical rapamycin appears to be a potentially efficacious, well‐tolerated, non‐invasive therapy in APACHE, although further studies are needed.
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Keywords: acral pseudolymphomatous angiokeratoma of children; angiokeratoma; rapamycin; sirolimus

Document Type: Research Article

Publication date: September 1, 2020

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