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S100‐Negative Indeterminate Cell Histiocytosis in an African American Child Responsive to Narrowband Ultraviolet B

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Abstract:  Indeterminate cell histiocytosis is a rare cutaneous disease characterized by the presence of dendritic cells that lack Birbeck granules and immunophenotypically shares features of both Langerhans cells and macrophages. We describe a case of a 4‐year‐old African American boy affected by a disseminated, exclusively mucocutaneous form of indeterminate cell histiocytosis. The eruption was successfully treated with narrowband ultraviolet B. The peculiar negativity of the Langerhans cell marker S100 is also discussed.
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Document Type: Research Article

Affiliations: Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida

Publication date: September 1, 2011

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