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Basal Cell Carcinoma Arising in a Nevus Sebaceus in a Child with Facial Trichoepitheliomas

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Abstract: 

Nevus sebaceus (NS) is a congenital skin hamartoma that presents in childhood. Tumors may arise within these lesions over time. Mutations in the PTCH gene have been associated with both NS and some of the developing tumors. Only nine documented cases of basal cell carcinoma arising in nevus sebaceus in childhood are available. We present a case of an 8-year-old male with nevus sebaceus who developed a basal cell carcinoma. Evaluation for constitutional PTCH gene mutation and loss of heterozygosity (LOH) from the BCC within the NS did not reveal an underlying mutation. We further discuss the literature regarding prophylactic excision of NS.
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Document Type: Research Article

Affiliations: 1: Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah 2: Pediatric Dermatology Clinic, Primary Children’s Medical Center, Salt Lake City, Utah 3: Department of Genetics, Yale School of Medicine, New Haven, Connecticut

Publication date: March 1, 2011

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