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Interstitial Granulomatous Lesions as Part of the Spectrum of Presenting Cutaneous Signs in Pediatric Sarcoidosis

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Abstract: 

Skin findings in childhood sarcoidosis vary greatly, but only a few occurrences have been published in which the histopathology has been characterized well. We describe a child with sarcoidosis in whom the cutaneous findings were atypical, resembling granuloma annulare. Histologic examination of these cutaneous lesions, however, revealed areas of sarcoid-like epithelioid cell granulomas, a palisading granulomatous process with features of granuloma annulare, as well as palisading neutrophilic and granulomatous dermatitis and interstitial granulomatous dermatitis. This underscores the variability of skin findings in childhood sarcoidosis—even within the same patient—and suggests that sarcoidosis should be considered in the differential diagnosis of children initially diagnosed with granulomatous skin lesions, such as granuloma annulare, palisading neutrophilic, and granulomatous dermatitis or interstitial granulomatous dermatitis, who demonstrate associated signs of systemic disease.
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Document Type: Research Article

Affiliations: 1: School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 2: Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 3: Section of Dermatology, Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 4: Division of Ophthalmology, Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 5: Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania 6: Division of Pathology, Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 7: Division of Rheumatology, Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

Publication date: September 1, 2007

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