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Erythrokeratoderma Variabilis Successfully Treated with Topical Tazarotene

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Erythrokeratoderma variabilis, also known as Mendes da Costa syndrome, is a genodermatosis belonging to the group of diseases known as the erythrokeratodermias. Erythrokeratoderma variabilis is characterized by two distinctive manifestations: well-demarcated, variable, transient, figurate patches of erythema, and localized or generalized hyperkeratotic plaques. Treatments include topical retinoic acid, salicylic acid, and alpha-hydroxy acid in petrolatum, but all have been reported to have limited, variable success rates. We report a child with erythrokeratoderma variabilis with no family history of this entity, successfully treated with topical tazarotene.
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Document Type: Research Article

Affiliations: 1: Department of Dermatology, University of Texas Southwestern, Dallas, Texas 2: David Geffen School of Medicine at the University of California, Los Angeles, California 3: Department of Dermatology, Harbor-UCLA Medical Center, Torrance, California 4: Division of Dermatology, University of California, Los Angeles, California

Publication date: July 1, 2006

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