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Neutrophilic Dermatoses in Two Children with Idiopathic Neutropenia: Association with Granulocyte Colony-Stimulating Factor (G-CSF) Therapy

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Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia. A girl with cystic fibrosis and cyclic neutropenia developed an erythematous papular eruption without fever or neutrophilia 7 months after commencing therapy with G-CSF. A skin biopsy specimen revealed microscopic, sterile, neutrophilic abscesses. A boy with chronic neutropenia and recurrent inflammatory skin lesions developed multiple erythematous nodules following administration of G-CSF. A biopsy specimen showed neutrophilic panniculitis. We believe that these skin eruptions belong to a spectrum of neutrophilic dermatoses that can be induced or aggravated by G-CSF therapy.
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Document Type: Research Article

Affiliations: 1: Division of Dermatology, British Columbia’s Children’s Hospital and University of British Columbia, Vancouver, Canada 2: Department of Pediatrics, British Columbia’s Children’s Hospital and University of British Columbia, Vancouver, Canada 3: Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri

Publication date: October 1, 2001

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