Skip to main content
padlock icon - secure page this page is secure

Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date

Buy Article:

$59.00 + tax (Refund Policy)

Abstract 

Probiotics, defined as live organisms that, when ingested in adequate amounts, exert a health benefit on the host, have been used for almost a century in the management of a variety of medical disorders, usually on the basis of little evidence. Advances in our understanding of the gut flora and of its relationship to the host, together with progress in microbiology, molecular biology and clinical research have identified important biological properties for probiotics and demonstrated efficacy in a number of gastrointestinal disorders. The clear delineation of a post-infective variety of irritable bowel syndrome (IBS), as well as the description, in a number of studies, of evidence of low-grade inflammation and immune activation in IBS, suggest a role for a dysfunctional relationship between the indigenous flora and the host in IBS and, accordingly, provide a clear rationale for the use of probiotics in this disorder. Other modes of action, including bacterial displacement and alterations in luminal contents, are also plausible. While clinical evidence of efficacy is now beginning to emerge, a review of available trials emphasises the importance of clear definition of strain selection, dose and viability. This is evidently an area of great potential in IBS and deserves further study at all levels.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: gut flora; irritable bowel syndrome; microbiota; probiotics

Document Type: Review Article

Affiliations: 1: Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland 2: Department of Gastroenterology, Centre Hospitalier Lyon-Sud, Pierre-Benite, France

Publication date: March 1, 2007

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more