@article {Ramos‐Martínez:2017:0933-7407:808,
title = "Epidemiology and prognosis of candidaemia in elderly patients",
journal = "Mycoses",
parent_itemid = "infobike://bsc/myc",
publishercode ="bp",
year = "2017",
volume = "60",
number = "12",
publication date ="2017-12-01T00:00:00",
pages = "808-817",
itemtype = "ARTICLE",
issn = "0933-7407",
eissn = "1439-0507",
url = "https://www.ingentaconnect.com/content/bsc/myc/2017/00000060/00000012/art00007",
doi = "doi:10.1111/myc.12677",
keyword = "mortality, aged, central venous catheters, antifungal agents, candidaemia",
author = "RamosMart{\’ı}nez, Antonio and VicenteL{\’o}pez, Natalia and S{\’a}nchezRomero, Isabel and Padilla, Bel{\’e}n and MerinoAmador, Paloma and GarnachoMontero, Jos{\’e} and RuizCamps, Isabel and Montejo, Miguel and Salavert, Miguel and Mensa, Jos{\’e} and CuencaEstrella, Manuel and the Members of the CANDIPOP Project from GEIHGEMICOMED (SEIMC) and REIPImyc12677-cr-0012",
abstract = "The aim of the study was to analyse the epidemiology and prognosis of candidaemia in elderly patients. We performed a comparison of clinical presentation of candidaemia according to age and a study of hazard factors within a prospective programme performed in 29 hospitals. One hundred
and seventysix episodes occurred in elderly patients (>75 years), 227 episodes in middleaged patients (6175 years) and 232 episodes in younger patients (1660 years). Central venous catheter, parenteral nutrition, neutropenia, immunosuppressive therapy and
candidaemia caused by Candida parapsilosis were less frequent in elderly patients. These patients received inadequate antifungal therapy (57.3%) more frequently than middleaged and younger patients (40.5% P < .001). Mortality during the first week (20%) and 30 days (42%) was higher
in elderly patients. The variables independently associated with mortality in elderly patients during the first 7 days were acute renal failure (OR: 2.64), Pitt score (OR: 1.57) and appropriate antifungal therapy (OR: 0.132). Primary candidaemia (OR: 2.93), acute renal failure (OR: 3.68),
Pitt score (OR: 1.38), appropriate antifungal therapy (OR: 0.3) and early removal of the central catheter (OR: 0.47) were independently associated with 30day mortality.In conclussion, inadequate antifungal treatment is frequently prescribed to elderly patients with candidaemia and
is related with early and late mortality.",
}