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Non‐response to fluconazole maintenance treatment (ReCiDiF regimen) for recurrent vulvovaginal candidosis is not related to impaired glucose metabolism

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Is non‐response to maintenance treatment for recurrent vulvovaginal candidosis (RCVV) related to the impaired glucose metabolism? In the ReCiDiF trial, women with RCVV were given a degressive regimen with fluconazole according to their clinical, microscopic and mycologic response. Data obtained from optimal, suboptimal and non‐reponding patients were used for secondary analysis of medical history, physical status and family history for potential glucose impairment. Results were presented in means and percentages. Pearson chi‐square, Fisher exact, Mann‐Whitney U, Kruskal‐Wallis and Spearman's correlation coefficient was calculated. P<.05 were interpreted as statistically significant. Sociodemographic characteristics and family and personal history of diabetes were not different between optimal, suboptimal and non‐responders. The average HbA1c concentration was 5.1±0.3% in optimal, 5.0±0.4% in sub‐optimal, and 5.1±0.3% in non‐responding patients (P=1.0). There are no statistical differences between optimal, sub‐optimal and non‐respondents to treatment in all deciles of HbA1c among patients with recurrent candidosis (P=1.0). There was no difference among groups in fasting glucose concentration, nor after 30 min, 60 min or 120 min during the oral glucose tolerance test (OGTT) (P=.6). Area under the OGTT curve did not differ within groups (P=.8), nor was the deviation from the normal cut‐off value any different (P=.8). Glucose concentration in vaginal rinsing fluid showed no correlation with responsiveness to treatment (P=.7). Glucose metabolism, BMI, personal or family history of diabetes are not related to non‐response to maintenance treatment with fluconazole for patients with RVVC.
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Keywords: diabetes; fluconazole maintenance therapy; impaired glucose metabolism; recurrent vulvovaginal candidiasis; treatment response; vaginal candidosis

Document Type: Research Article

Publication date: August 1, 2017

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