Skip to main content
padlock icon - secure page this page is secure

Evaluation of topical antifungal products in an in vitro onychomycosis model

Buy Article:

$52.00 + tax (Refund Policy)

Many topical commercial products are currently available for the treatment of onychomycosis. However, limited data are available concerning their antifungal activity. Using an in vitro onychomycosis model, the daily application of seven nail formulations was compared to the antifungal reference drug amorolfine (Loceryl®) and evaluated for inhibitory activity against Trichophyton mentagrophytes using an agar diffusion test. Of all commercial nail formulations, only Excilor® and Nailner® demonstrated inhibitory activity, which was much lower compared to the daily application of Loceryl®. However, Excilor® showed similar efficacy compared to the conventional weekly application of Loceryl®. These results suggest a role for organic acids in the antifungal effect of Excilor® (acetic acid, ethyl lactate) and Nailner® (lactic acid, citric acid, ethyl lactate) as all tested formulations without organic acids were inactive.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Trichophyton mentagrophytes; in vitro; onychomycosis; topical antifungals

Document Type: Research Article

Publication date: May 1, 2016

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more