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Meningitis caused by Filobasidium uniguttulatum: case report and overview of the literature

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Cryptococcal meningitis is mainly caused by Cryptococcus neoformans and Cryptococcus gattii, but occasionally other Cryptococcus species and phylogenetically related species are involved. Herein, we present a case of cryptococcal meningitis from China, which was caused by an azole and flucytosine resistant Filobasidium uniguttulatum. In addition, we present an overview of the literature of meningitis caused by Cryptococcus species other than C. neoformans and C. gattii. Eight cases were related to infections of the central nervous system. Leukaemia and cancer were important risk factors in HIV‐negative patients. Molecular identification and susceptibility testing are important for proper management of patients because the species involved may differ in susceptibility to antifungal drugs.
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Document Type: Research Article

Affiliations: 1: , Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, China 2: CBS-KNAW Fungal Biodiversity Centre, Yeast and Basidiomycete Research, Utrecht, The Netherlands 3: Department of Dermatology, Shanghai First People’s Hospital, Shanghai, China 4: Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands

Publication date: March 1, 2012

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