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Cutaneous hyalohyphomycosis by Scedosporium apiospermum in an immunocompromised patient

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Scedosporium apiospermum is a ubiquitous filamentous fungus that may infect immunocompetent patients after trauma and may cause severe and often fatal infections in immunocompromised hosts. Here, we present the case of a 28-year-old female with S. apiospermum infection on the left forearm that had developed while she was on long-term immunosuppressant therapy. Analysis of a skin biopsy specimen showed a mixed cell granuloma with hyaline septate hyphae. Culture of the abscess revealed S. apiospermum which was identified as S. apiospermum sensu stricto by sequencing of the internal transcribed spacer-1 region of ribosomal DNA genes. Resection of the eruption and oral itraconazole (100 mg day−1) therapy for 4 months was effective in curing the infection.
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Document Type: Research Article

Affiliations: 1: Department of Dermatology and Plastic Surgery, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan 2: Department of Dermatology, Japan Seafarers Relief Association Nagasaki Hospital, Nagasaki, Japan

Publication date: May 1, 2011

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