Isolation of Aspergillus udagawae from a fatal case of feline orbital aspergillosis
Aspergillus fumigatus is the predominant etiological agent of sino-orbital aspergillosis in humans and animals. Here we report for the first time A. udagawae, a previously recognised but rare opportunistic pathogen causing fatal orbital aspergillosis in a cat. Identification of this isolate was secured by comparative sequence based analyses of the ITS and the β tubulin region. Antifungal susceptibility testing results revealed that this isolate had high in vitro MIC to amphotericin B (AMB) that correlated with in vivo failure of therapy with AMB.
Document Type: Research Article
Affiliations: 1: Department of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan 2: Department of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan 3: Department of Veterinary Clinical Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan 4: Department of Pathobiology, Nihon University School of Veterinary Medicine, Kanagawa, Japan 5: Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
Publication date: July 1, 2008