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Isolation of Aspergillus udagawae from a fatal case of feline orbital aspergillosis

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Aspergillus fumigatus is the predominant etiological agent of sino-orbital aspergillosis in humans and animals. Here we report for the first time A.¬†udagawae, a previously recognised but rare opportunistic pathogen causing fatal orbital aspergillosis in a cat. Identification of this isolate was secured by comparative sequence based analyses of the ITS and the β tubulin region. Antifungal susceptibility testing results revealed that this isolate had high in vitro MIC to amphotericin B (AMB) that correlated with in vivo failure of therapy with AMB.
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Document Type: Research Article

Affiliations: 1: Department of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan 2: Department of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan 3: Department of Veterinary Clinical Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan 4: Department of Pathobiology, Nihon University School of Veterinary Medicine, Kanagawa, Japan 5: Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA

Publication date: July 1, 2008

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