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The use of glucan as immunostimulant in the treatment of a severe case of chromoblastomycosis

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Summary

We report the case of an alternative treatment for a patient with a severe form of chromoblastomycosis that responded poorly to the traditional antifungal therapy. We hereby show, in this study, the improvement of lesions after treatment with itraconazole associated with an intramuscular administration of glucan. We observed that the regression of lesions was associated with an improvement of the cellular immune response. This favourable response that we observed suggests that the therapeutic regimen we used might be an option for the treatment of patients with a severe form of chromoblastomycosis.
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Document Type: Research Article

Affiliations: 1: Departamento de Patologia, Universidade Federal do Maranhão, Maranhão, Brazil 2: Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil 3: Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil

Publication date: July 1, 2008

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