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Comparison of in vitro activities of antifungal drugs and ethanolic extract of propolis against Trichophyton rubrum and T. mentagrophytes by using a microdilution assay

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The in vitro activities of propolis against 29 strains of dermatophytes were compared with those of terbinafine, itraconazole, ketoconazole, and fluconazole. Minimal inhibitory concentrations (MICs) were determined according to a National Committee for Clinical Laboratory Standards broth microdilution method. Among the systemic antifungals tested, terbinafine was the most potent. Propolis showed important antifungal activity and it merits further investigation as a potentially useful agent for the treatment of dermatophytosis.
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Keywords: antifungal activity; antifungal agents; dermatophytes; microdilution method; propolis

Document Type: Research Article

Affiliations: 1: Medical Faculty, Department of Microbiology, Erciyes University, Kayseri 2: Department of Animal Science, S.Çıkrıkçıogˇlu Vocational College, Erciyes University, Kayseri 3: Medical Faculty, Department of Dermatology, Erciyes University, Kayseri 4: Faculty of Agriculture, Department of Animal Science Biometry and Genetics, Çukurova University, Adana, Turkey

Publication date: May 1, 2005

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