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In vitro susceptibilities of 11 clinical isolates of Exophiala species to six antifungal drugs

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The antifungal activities of miconazole, terbinafine, itraconazole, UR 9825, voriconazole and amphotericin B against 11 clinical isolates of Exophiala spp. were tested by the broth microdilution method. All drugs were very active against Exophiala spp.. The 90% minimal inhibitory concentration (MIC90) ranged from 0.125 to 1 μg ml−1. Terbinafine was the most active drug against Exophiala spinifera, Exophiala dermatitidis and Exophiala castellanii and seems to be a promising agent in the treatment of infections caused by these fungi.
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Document Type: Research Article

Affiliations: 1: Department of Medical Microbiology, University Hospital Nijmegen, Nijmegen, The Netherlands 2: Centraalbureau voor Schimmelcultures, Baarn, The Netherlands

Publication date: September 1, 2000

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