Skip to main content
padlock icon - secure page this page is secure

Changes of virulence factors accompanying the phenomenon of induced fluconazole resistance in Candida albicans

Buy Article:

$52.00 + tax (Refund Policy)


We investigated a fluconazole-sensitive (MICflu = 5 μg ml−1) clinical isolate and a fluconazole-resistant (MICflu >80 μg ml−1) laboratory mutant Candida albicans strain developed from the sensitive one. We studied putative virulence factors including germination, adherence ability to either buccal epithelial cells or acrylate surface, the secreted aspartic proteinase, and the extracellular phospholipase activity of the two strains as well as their growth. The fluconazole-resistant strain proved to be superior to the original strain in all the virulence traits tested. The higher virulence of the fluconazole-resistant strain was also supported by a mouse model. These results suggest that the development of fluconazole resistance can be accompanied by serious morphological and physiological changes: several putative virulence traits, moreover the in vivo virulence can increase simultaneously.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: Department of Microbiology and Biotechnology, Kossuth Lajos University 2: BIOGAL Pharmaceutical Factory Ltd, Debrecen, Hungary

Publication date: September 1, 2000

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more