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Results of a Combination Treatment with Natamycin and Butylscopolamine in Cases of Intestinal Candida Colonization

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The findings described show that Candida species can be found in the feces of approximately half a population of non‐selected test persons and in the mouths of approximately a third. Intestinal Candida colonization was found in most of these persons after one feces examination, and in practically all of them after a second examination. 10 d of therapy with 400 mg natamycin per day in sugarcoated tablet form and 40 mg natamycin in the form of tablets for sucking produced a negative fungus test for the feces in only 20 % of the cases. Although a combination of this therapy with 3 x 10 mg butylscopolamine per day improved short‐term results significantly, the long‐term results were hardly influenced at all. Typifying results according to the Warnock method showed that we are dealing with recurrences in practically all cases and not with new infections. Minimal inhibition concentrations (MIC) of natamycin showed no marked changes as a consequence of the natamycin treatment.
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Keywords: Butylscopolamin; Intestinal Candida colonization; Intestinale Candida-Besiedlung; Mundabstriche; Natamycin; Stuhluntersuchung; butylscopolamine; feces examination; mouth examination; natamycin

Document Type: Research Article

Affiliations: Hautklinik am Klinikum der Stadt Karlsruhe, Germany FR

Publication date: March 1, 1990

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