@article {Nakamura:1993:0950-382X:225,
title = "Control and function of lysyltRNA synthetases: diversity and coordination",
journal = "Molecular Microbiology",
parent_itemid = "infobike://bsc/mole",
publishercode ="bp",
year = "1993",
volume = "10",
number = "2",
publication date ="1993-10-01T00:00:00",
pages = "225-231",
itemtype = "ARTICLE",
issn = "0950-382X",
eissn = "1365-2958",
url = "https://www.ingentaconnect.com/content/bsc/mole/1993/00000010/00000002/art00002",
doi = "doi:10.1111/j.1365-2958.1993.tb01948.x",
author = "Nakamura, Yoshikazu and Ito, Koichi",
abstract = "Summary LysyltRNA synthetases are synthesized from two distinct genes in Escherichia coli, lysS (constitutively) and lysU (inducibly); however, the physiological significance and the differential control mechanism of these
two genes have been a longstanding puzzle. Recent studies have successfully uncovered a significant control mechanism of lysU expression, which involves the leucineresponsive regulatory protein (Lrp) and a translational enhancer element calleddownstream box'.
Moreover, it is likely that there is a mechanism underlying coordinate expression of lysU with other genes outside the leucineLrp regulon under harsh conditions such as low pH and anaerobiosis. A possible mechanism of lysyltRNA synthetase expression and function
is reviewed.",
}