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Control and function of lysyl‐tRNA synthetases: diversity and co‐ordination

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Lysyl‐tRNA synthetases are synthesized from two distinct genes in Escherichia coli, lysS (constitutively) and lysU (inducibly); however, the physiological significance and the differential control mechanism of these two genes have been a long‐standing puzzle. Recent studies have successfully uncovered a significant control mechanism of lysU expression, which involves the leucine‐responsive regulatory protein (Lrp) and a translational enhancer element called‘downstream box'. Moreover, it is likely that there is a mechanism underlying co‐ordinate expression of lysU with other genes outside the leucine‐Lrp regulon under harsh conditions such as low pH and anaerobiosis. A possible mechanism of lysyl‐tRNA synthetase expression and function is reviewed.
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Document Type: Research Article

Affiliations: Department of Tumor Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan.

Publication date: October 1, 1993

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