Skip to main content
padlock icon - secure page this page is secure

Free Content Adaptive servo-ventilation and deadspace: effects on central sleep apnoea

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library


Central Sleep Apnoea (CSA) occurs commonly in heart failure. Adaptive servo-ventilation (ASV) and deadspace (DS) have been shown in research settings to reverse CSA. The likely mechanism for this is the increase of PaCO2 above the apnoeic threshold. However the role of increasing FiCO2 on arousability remains unclear. To compare the effects of ASV and DS on sleep and breathing, in particular effects on Arousal Index (ArI), ten male patients with heart failure and CSA were studied during three nights with polysomnography plus measurements of PetCO2. The order of the interventions control (C), ASV and DS was randomized. ASV and DS caused similar reductions in apnoea–hypopnoea index [(C) 30.0 ± 6.6, (ASV) 14.0 ± 3.8, (DS) 15.9 ± 4.7 e h−1; both P < 0.05]. However, DS was associated with decreased total sleep time compared with C (P < 0.02) and increased spontaneous ArI compared to C and ASV (both P < 0.01). Only DS was associated with increased ΔPetCO2 from resting wakefulness to eupnic sleep [(C) 2.1  ± 0.9, (ASV) 1.3 ± 1.0, (DS) 5.6 ± 0.5 mmHg; P = 0.01]. ASV and DS both stabilized ventilation however DS application also increased sleep fragmentation with negative impacts on sleep architecture. We speculate that this effect is likely to be mediated by increased PetCO2 and respiratory effort associated with DS application.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: arousability; control of breathing; deadspace; heart failure

Document Type: Research Article

Affiliations: Academic Unit of Sleep and Breathing

Publication date: June 1, 2006

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more