Skip to main content
padlock icon - secure page this page is secure

Pioglitazone promotes peripheral nerve remyelination after crush injury through CD36 upregulation

Buy Article:

$52.00 + tax (Refund Policy)


In our previous study, we found that CD36-deficient mice showed significant delays in peripheral nerve remyelination after sciatic nerve crush injury and suggested that CD36 played an important role in the restoration of injured peripheral nerves. The aim of this study was to investigate whether CD36 upregulation can promote peripheral nerve remyelination. We made crush injury that caused demyelination and mild axonal degeneration to sciatic nerves and investigated the effect of pioglitazone (PIO) on the remyelination post-injury in C57Bl/6 wild-type and CD36-deficient mice. The immunohistochemistry with anti-CD36 antibody showed that CD36 was upregulated in macrophages infiltrating peripheral nerves from the wild-type mice by PIO administration at 1 week post-injury. The lectin histochemistry represented that infiltrating macrophages lessened in the wild-type mice at 3 weeks post-injury by PIO administration. General histopathology and morphometry indicated that thinly myelinated fibers and naked axons diminished in PIO-treated wild-type mice compared with non-treated wild-type mice at 3 weeks post-injury. No significant differences were observed in remyelination and number of infiltrating macrophages between PIO-treated and non-treated CD36-deficient mice. These results indicate that PIO promotes peripheral nerve remyelination possibly through CD36. It may be possible to apply PIO to the remedy against demyelinating neuropathies.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: C57Bl/6; RCA-1; macrophage; scavenger receptor; thiazolidinedione

Document Type: Research Article

Affiliations: 1: Department of Neurology, Osaka University Graduate School of Medicine, Osaka 2: Division of Neurology, National Hospital Organization Toneyama National Hospital, Osaka 3: Department of Internal Medicine, Division of Neurology and Stroke Care Unit, Hyogo College of Medicine, Hyogo, Japan

Publication date: September 1, 2008

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more