Skip to main content
padlock icon - secure page this page is secure

Small Rho GTPases are key regulators of peripheral nerve biology in health and disease

Buy Article:

$52.00 + tax (Refund Policy)

Abstract

A thorough knowledge of the cellular and molecular basis of the structure and function of peripheral nerves is of paramount importance not only for a better understanding of the fascinating biology of the peripheral nervous system but also for providing critical insights into the various diseases affecting peripheral nerves as the firm foundation of potential treatments. Genetic approaches in model organisms, in combination with research on hereditary forms of neuropathies, have contributed significantly to our progress in this field. In this review, we will focus on recent advances using these synergistic approaches that led to the identification of small Rho GTPases and their regulators as crucial functional players in proper development and function of myelinated peripheral nerves, with a particular emphasis on the cell biology of Schwann cells in health and disease.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Cdc42; Charcot-Marie-Tooth disease; Rac; Rho; Rho GTPase; Schwann cell; myelin; peripheral neuropathy; phosphoinositide

Document Type: Research Article

Affiliations: Institute of Cell Biology, Department of Biology, ETH Zürich, Zürich, Switzerland

Publication date: September 1, 2008

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more