Skip to main content
padlock icon - secure page this page is secure

Laminins and their receptors in Schwann cells and hereditary neuropathies

Buy Article:

$52.00 + tax (Refund Policy)

Abstract 

This review focuses on the influence of laminins, mediated through laminin receptors present on Schwann cells, on peripheral nerve development and pathology. Laminins influence multiple aspects of cell differentiation and tissue morphogenesis, including cell survival, proliferation, cytoskeletal rearrangements, and polarity. Peripheral nerves are no exception, as shown by the discovery that defective laminin signals contribute to the pathogenesis of diverse neuropathies such as merosin-deficient congenital muscular dystrophy and Charcot-Marie-Tooth 4F, neurofibromatosis, and leprosy. In the last 5 years, advanced molecular and cell biological techniques and conditional mutagenesis in mice began revealing the role of different laminins and receptors in developing nerves. In this way, we are starting to explain morphological and pathological observations beginning at the start of the last century. Here, we review these recent advances and show how the roles of laminins and their receptors are surprisingly varied in both time and place.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Schwann cell; congenital muscular dystrophy; dystroglycan; integrin; laminin; mice; myelin; node of Ranvier; radial sorting; targeted mutagenesis

Document Type: Research Article

Affiliations: San Raffaele Scientific Institute, DIBIT, Milano, Italy

Publication date: June 1, 2005

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more