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Anterograde TNFα Transport From Rat Dorsal Root Ganglion To Spinal Cord And Injured Sciatic Nerve

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Tumor necrosis factor‐α (TNFα) is a key modulator of painful peripheral nerve injury. We have previously shown that a tracer of TNFα injected at the site of rat sciatic nerve injury undergoes retrograde axonal transport to the dorsal root ganglia (DRG). To further understand the role of TNFα in DRG, we injected rat L5 DRG with biotinylated TNFα, neurobiotin, or vehicle, and detected translocation of the biotin tag by avidin‐biotin histochemistry. Biotinylated TNFα was transported intraaxonally toward the periphery of both normal and injured nerves. It also reached the dorsal horn of the spinal cord in injured rats, but not in control rats. These findings highlight a dynamic process of TNFα axonal transport in the peripheral neural axis, and help explain activation of central cytokines in the pathogenesis of painful neuropathy.
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Document Type: Research Article

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Publication date: September 1, 2002

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