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The endoneurial response to microsurgically removed epi‐ and perineurium

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Abstract  The purpose of the study was to examine the response of the endoneurium of the rat sciatic nerve after removal of the epi‐ and perineurium. For this purpose, segments (4–5 mm long) of the whole epi‐ and perineurium around the rat sciatic nerve were microsurgically removed (the peel‐off area) and the endoneurium was left intact. The postoperative changes were followed up to 5 weeks post‐operatively (PO) by histo‐ and immunohistochemical studies. Additionally, neuromorphometric analyses considering the number of Schwann cells, axons, macrophages and endothelial cells were examined in the peel‐off area.
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Keywords: Wallerian degeneration; peripheral nerve injury; regeneration

Document Type: Research Article

Affiliations: University of Turku, Kiinanmyllynkatu, Turku, Finland

Publication date: September 1, 2002

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