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Antiganglioside antibodies in acute self-limiting ataxic neuropathy: incidence and significance

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Antidisialosyl antibodies have been previously associated to chronic and acute ataxic neuropathies. We studied the presence of these antibodies in nine patients with acute self-limiting ataxic neuropathy (ASLAN) using ELISA and TLC immunodetection. One patient showed serum IgG immunoreactivity against gangliosides GD3 and GQlb. The patient's IgG was able to bind to the nodes of Ranvier on frozen human dorsal root. Our studies confirmed that antidisialosyl reactivity is associated to ataxic neuropathy and its specific binding to the dorsal root could explain the predominant sensory involvement. Nevertheless, the low incidence of this reactivity indicates that a different pathogenic mechanism should be involved in most ASLAN patients.
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Document Type: Research Article

Affiliations: Journal of Neuroimmunology 120: 78–83, 2001. Reprinted with permission from Elsevier Science BV.

Publication date: June 1, 2002

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