Skip to main content
padlock icon - secure page this page is secure

Abnormal Schwann Cell-Axon Interaction In EBF-2 “Knock Out” Mice

Buy Article:

$52.00 + tax (Refund Policy)

Ebf-2 belongs to the Ebf gene family which has been implicated in various aspects of neural development. In the peripheral nervous system, Ebf-2 is highly expressed in immature Schwann cells. Ebf-2 expression is maintained in non myelin-forming Schwann cells, whereas it is down-regulated in myelin-forming Schwann cells. Although its exact role is still unclear, putative target genes include molecules involved in Schwann cell differentiation and maturation such as SCIP, N-CAM, L1, laminin, and the intermediate filament GFAP. Disruption of Ebf-2 affects nerve development and results in a defective Schwann cell-axon interaction. Deficient sorting of large calibre axons that lie in bundles in non-myelin-forming Schwann cells, associated in some cases with abnormal myelination, are the main characteristic features. This is likely the result of an aberrant communication between Schwann cells and axons.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Abstract

Affiliations: Dept. Neurosciences and DIBIT, San Raffele Scientific Institute.

Publication date: March 1, 2001

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more