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Power Spectral Analysis Of Heart Rate In Uremic Autonomic Neuropathy: Relation To Age

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Background: Autonomic derangement occurs frequently in chronic uremics. It is consistent with a parasympathetic and sympathetic damage, with some clinical sequelae. Power Spectral Analysis (PSA) of heart rate variability in frequency domain is an effective way for evaluating the autonomic function in different pathological conditions. The aim of the study was the evaluation of PSA variation in relation to age in chronic uremics. Materials and methods: We studied 24 uremic patients on intermittent haemodialysis, aged 34–75 years (mean age ± SD; 54.5 ± 14), and 24 age-matched controls by PSA. Low frequency band (LF) is considered a marker of sympathetic component, high frequency band (HF) of parasympathetic control and LF/HF ratio reflects the sympatho-vagal balance. Both control and uremic subjects were divided into two subgroups according to age under or above 65 years. Results: A significant reduction of LF components in middle age and elderly uremics was found when compared to controls, indicating a sympathetic pattern involvement. There was also a significant difference between middle age and elderly uremics for LF band. Comparing the linear regression models (age vs each test), correlation coefficient was significantly different in standing LF values between controls and uremics, while slope and intercept were not. Comment: Preliminary results indicate that aging is not a significant variable in uremic patients affected by autonomic neuropathy.
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Document Type: Abstract

Affiliations: Institute of Neurological and Neurosurgical Sciences, Unit of Nephrology, University of Messina, Italy

Publication date: March 1, 2001

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